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KMID : 0377519950200040377
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Chung-Ang Journal of Medicine
1995 Volume.20 No. 4 p.377 ~ p.386
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Expression of nm23 Protein in Malignant Epithelial Tumors
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Yoo Yeon-Sik
Lee Tae-Jin
Park Eon-Sub
Yoo Jae-Hyung
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Abstract
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To elucidate the expression of the human nm23, known as a candidate metastatic supressor gene of various malignant epithelial tumors, immunohistochemical studies were carried out by using avidin-biotin complex immunoperoxidase method in paraffin embedded tissue sections from 79 cases. This studies consisted of 10 cases of gastric adenocarcinoma, 10 cases of colonic adenocarcinoma, 14 cases of periampullary caricnoma, 5 cases of gallbaldder carcinoma, 10 cases of hepatic adenocarcinoma, 10 cases of bronchogenic carcinoma, 10 cases of uterine cervical squamous cell carcinoma and 10 cases of breast carcinoma. The results were as follows ; 1. The nm23 protein expression was found to the intracytoplasmic portion of the neoplastic cells with homogenous and/or heterogenous staining intensity. 2. The cytoplasmic staining for nm23 protein was identified in normal and cancer tissue. However, the immunoreactive staining intensity was more stonger in cancer tissue than that of normal mucosal tissue. 3. The frequency of nm23 protein expression in various malignant epithelial tumors observed in this study was 56.9%(45 out of 79 cases); colonic adenocarcinoma(90%), bronchogenic carcinoma(90%), uterine cervical squamous cell carcinoma(70%), gastric adenocarcinoma(60%), breast carcinoma(50%), periampully carinoma(35.7%), hepatic adenocarcinoma(30%) and gallbladder carinoma(20%). 4. The well differentiated carcinoma showed strong immunoreactive nm23 tumor cells than that of poorly differentiated carcinoma. Therefore, author suggested that nm23 protein expression was associated with differentiation of tumor cells, regardless of tumor site or specific type.
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KEYWORD
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nm23 protein, malignant epithelial tumors
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